A Comprehensive Review of PT-141
Researchers will find comprehensive information on PT-141 peptides below. Bremelanotide, often referred to as PT-141, has been extensively studied in animal model research related to libido, particularly with a focus in menopause. Currently, scholars are conducting investigations of peptide exposure in male research models of sexual dysfunction, encompassing ailments such as erectile dysfunction and diminished sexual and reproductive behavior.
PT-141 Peptide: What is it?
PT-141 is a peptide derivative of α-Melanocyte-stimulating hormone (α-MSH), a naturally occurring melanotropin that may promote the production of melanin and regulate sexual activity. Studies suggest that the peptide may strongly attract melanocortin iii and iv receptors (MC3-R and MC4-R), which are extensively present in the brain and linked to reproductive and sexual action. Research indicates that PT-141 may operate distinctly compared to other approaches for erectile dysfunction via vasodilation to increase blood flow. In contrast, PT-141 has been hypothesized to directly transmit signals to the neural connections accountable for arousal in research models of both sexes.
PT-141 Peptide and PDE5
A study done in 2004 aimed to investigate the impact of PT-141 on research models of erectile dysfunction (ED) following exposure to a PDE5 inhibitor. A statistically significant erectile response was speculated in the research models upon exposure to PT-141, as reported by the researchers.
In 2006, Iranian researchers performed a study to evaluate the peptide’s potential in erectile dysfunction (ED) under the same PDE5 inhibitor non-response. According to the study, the experimental group in the study, exposed to PT-141, appeared to have exhibited a significant increase in sexual behavior in comparison to the control group.
PT-141 Peptide and Mood
Melanocortin peptides have been suggested to facilitate dopamine neurotransmission. A two-week investigation on mice indicated alterations in the binding of dopamine D(1)-like receptors in different regions of the rodents’ brains after the intracerebroventricular presentation of Melanotan 2, which served as the initial source for the development of PT-141.
The authors proposed that over time, giving a melanocortin receptor agonist might induce alterations in dopaminergic neurons. They also claimed that the regulatory effects of melanocortin peptides, such as PT-141, on central dopamine neurons may potentially lead to general elevation in mood balance.
PT-141 Peptide and Libido
PT-141 (Bremelanotide) has been studied in relation to libido in female research models, as previously stated. The findings of a 52-week clinical study examining the potential and effectiveness of Bremelanotide in 856 research models of hypoactive sexual desire disorder (HSDD) indicate that the exposure to PT-141 appeared to have resulted in enduring enhancements in symptoms of hypoactive sexual desire disorder.
Traditional research in this area has led to the development of selective phosphodiesterase type 5 inhibitors. It has been studied in cases of moderate to severe erectile dysfunction (ED), and research has also extended as far as diabetes mellitus. The mechanism of action appears to involve the targeted inhibition of cGMP-specific phosphodiesterase type 5 (PDE5), a hormone present in all types of blood vessels.
A study was conducted to examine the possible impact of selective phosphodiesterase type 5 inhibitors on spermatogenesis or reproductive hormones. Over six months, the researchers suggested that the daily exposure of the inhibitors did not appear to impact spermatogen levels.
PT-141 Peptide: Reliable Online Source
PT-141 may be acquired via internet platforms by licensed researchers and laboratory personnel for scientific endeavors. Although many peptide providers are available, not all possess the same level of quality. For instance, several suppliers prioritize the quality of peptides and subject all of their goods to rigorous quality and purity testing conducted by a third-party laboratory. However, some do not adhere to these criteria and instead distribute peptides of questionable quality. www.corepeptides.com has extensive knowledge of the research peptides community, enabling you to make informed decisions on suppliers to engage with and those to steer clear of.
References
[i] Dhillon S, Keam SJ. Bremelanotide: First Approval. Drugs. 2019 Sep;79(14):1599-1606. doi: 10.1007/s40265-019-01187-w. PMID: 31429064.
[ii] Bremelanotide (Vyleesi) for hypoactive sexual desire disorder. Med Lett Drugs Ther. 2019 Jul 29;61(1577):114-116. PMID: 31381550.
[iii] Rosen RC, Diamond LE, Earle DC, Shadiack AM, Molinoff PB. Evaluation of the safety, pharmacokinetics and pharmacodynamic effects of subcutaneously administered PT-141, a melanocortin receptor agonist, in healthy male subjects and in patients with an inadequate response to Viagra. Int J Impot Res. 2004 Apr;16(2):135-42. doi: 10.1038/sj.ijir.3901200. PMID: 14999221.
[iv] Safarinejad MR, Hosseini SY. Salvage of sildenafil failures with bremelanotide: a randomized, double-blind, placebo controlled study. J Urol. 2008 Mar;179(3):1066-71. doi: 10.1016/j.juro.2007.10.063. Epub PMID: 18206919.
[v] Lindblom J, Kask A, Hägg E, Härmark L, Bergström L, Wikberg J. Chronic infusion of a melanocortin receptor agonist modulates dopamine receptor binding in the rat brain. Pharmacol Res. 2002 Feb;45(2):119-24. doi: 10.1006/phrs.2001.0913. PMID: 11846623.
[vi] Simon JA, Kingsberg SA, Portman D, Williams LA, Krop J, Jordan R, Lucas J, Clayton AH. Long-Term Safety and Efficacy of Bremelanotide for Hypoactive Sexual Desire Disorder. Obstet Gynecol. 2019 Nov;134(5):909-917. doi: 10.1097/AOG.0000000000003514. PMID: 31599847; PMCID: PMC6819023.
[vii] Haddad A, Jabbour M, Bulbul M. Phosphodiesterase type 5 inhibitors for treating erectile dysfunction and lower urinary tract symptoms secondary to benign prostatic hyperplasia: A comprehensive review. Arab J Urol. 2015 Sep;13(3):155-61. doi: 10.1016/j.aju.2015.06.004. Epub. PMID: 26413339; PMCID: PMC4563010.
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Source: Vietnam Insider